Building and maintaining the nucleus over a lifetime
We seek to understand how the organization of the cell nucleus is established, specialized across cell types, and maintained over time to influence cellular identity.
We are particularly interested in the nuclear lamina and the nuclear envelope, which make up the border of the eukaryotic nucleus and contribute to the spatial organization of the genome.
The nuclear lamina is essential for mammalian development. Mutations to lamins or associated proteins cause a cluster of “laminopathy” diseases that afflict the heart, muscle, bone, fat, and nervous system.
Major research themes include: (see Research to learn more)
Join us! Our mission is to make meaningful contributions to science while fostering an inclusive laboratory culture that values both individual growth and effective teamwork. We believe that a diversity of perspectives makes for a stronger, more creative team. Contact Abby to learn more, or visit us in Room 312 of the Smith Cardiovascular Research Building on UCSF’s Mission Bay campus.